Relative contributions of solid skeleton visco-plasticity and water viscosity to the poro-mechanics behavior of callovo-oxfordian claystone

The Callovo-Oxfordian claystone is a saturated porous medium. Its transfer properties, including its low permeability [16] make it an interesting candidate for underground radioactive waste disposal. The drained tests performed on the claystone, collected by ANDRA1 from samples at 500 meters depth [16, 9], exhibits a damageable visco-elasto-plastic behavior. This viscous behavior includes both the viscosity of the skeleton and the water. In existing models [5, 6, 11, 1], the creep phenomena are attributed either to the water permeability, to the skeleton visco-plasticity or sometimes both [13]. In a first step, a simplified analysis is proposed to understand the contribution of each phenomenon with respect to the consolidation time. This study indicates that the apparent characteristic time is the sum of those related to the skeleton and water permeability. To handle both non-linear and viscous phenomena, the damage law [15], coupled with the basic creep model [14] is used to characterize the solid skeleton of the claystone. The fluid behavior is integrated with the poro-mechanical model [7] implemented in the finite element code CAST3M [4]. The proposed model (visco-elastic damageable skeleton + saturating fluid) is used to simulate an excavation from the ANDRA underground laboratory (located in Bure–France). This application allows the understanding of how both viscous phenomena combine at each step of the calculation. Just after the excavation, water overpressure decreases near the gallery approaching zero due to the damage and then increases the permeability. The viscosity is then controlled by the solid skeleton creep rates. Later, the redistribution of hydraulic pressure is of more importance and permeability again plays a major role

Knowledge, attitude and practice of Lebanese community pharmacists with regard to self-management of low back pain

Purpose: To determine the knowledge, attitude and reported practice of Lebanese community pharmacists who advise persons who present with low back pain.Methods: This was a multi-center cross-sectional study conducted in over 300 community pharmacies across Lebanon from December 2017 to May 2018. Pharmacists working at a community pharmacy were considered eligible, and those who volunteered to participate completed the questionnaire. The questionnaire was designed for self-completion by the pharmacist and included demographic questions about the respondent, questions that assessed knowledge and attitude toward low back pain, and questions about treatment to reflect and characterize the nature of practice. The primary outcome was to determine the knowledge, attitude and reported practice of the Lebanese pharmacists advising people who presented with low back pain. The secondary outcome was to assess factors that affect knowledge, attitude, and practice.Results: The response of 320 community pharmacists was analysed. The proportion of pharmacists with good knowledge about low back pain (51. 7 %) was slightly higher than those with poor knowledge (48. 3 %). Oral therapy was the most prescribed dosage form for back pain compared to local patch and cream. Among oral dosage forms, non-steroidal anti-inflammatory drugs were the most prescribed medications (42 %). Of the patients’ referral to the physician if necessary, 73.1 % of the referrals were by pharmacists.Conclusion: Community pharmacists in Lebanon demonstrate an acceptable level of knowledge of back pain, yet major gaps still exist, particularly in terms of the quality of advice. Hence, more education is needed to provide better quality of advice. Keywords: Attitude, Knowledge, Low back pain, Reported practice, Quality of advic

Human respiratory syncytial virus in children hospitalized for acute lower respiratory infection

OBJETIVO: Avaliar a prevalência e a sazonalidade do vírus respiratório sincicial humano (VRSH) em crianças de 0 a 6 anos hospitalizadas por infecção aguda das vias aéreas inferiores (IVAI) em São José do Rio Preto (SP) e a associação entre faixa etária, diagnóstico e VRSH. MÉTODOS: Entre maio de 2004 e setembro de 2005, foram estudados 290 episódios consecutivos de IVAI adquiridos na comunidade em crianças de 0 a 6 anos internadas no Hospital de Base de São José do Rio Preto. Para identificação do VRSH, foram coletadas amostras de secreção de nasofaringe e realizou-se análise molecular por meio da técnica de RT-PCR. RESULTADOS: A prevalência de VRSH foi de 29,3% nos episódios de IVAI hospitalizados. A IVAI foi frequente em lactentes (mediana de idade = 13,5 meses). O VRSH foi mais frequente nos casos de bronquiolite (64%) e no primeiro ano de vida (35%). Os episódios de infecção por VRSH ocorreram entre o outono e a primavera, com frequência maior em 2004 do que em 2005. Os critérios clínicos e radiológicos não foram suficientes para o diagnóstico de infecção pelo VRSH. Em 78,8% dos episódios de VRSH, houve tratamento com antibiótico. CONCLUSÕES: A prevalência do VRSH em crianças de 0 a 6 anos hospitalizadas por IVAI foi elevada, com predomínio nas mais jovens ou com bronquiolite. A circulação do vírus variou nos dois anos estudados. Os resultados sugerem necessidade de diagnóstico laboratorial do VRSR na prática clínica.OBJECTIVE: To evaluate the prevalence and seasonality of human respiratory syncytial virus (HRSV) in children aged 0 to 6 years, hospitalized with acute lower respiratory infection (ALRI) in São José do Rio Preto, SP, Brazil, and the association between age, diagnosis, and HRSV. METHODS: Between May 2004 and September 2005, we studied 290 consecutive episodes of community-acquired ALRI in children aged 0 to 6 years admitted to the Hospital de Base of São José do Rio Preto. In order to detect HRSV, nasopharyngeal secretion samples were collected and RT-PCR molecular analysis was performed. RESULTS: The HRSV prevalence was 29.3% for the cases of hospitalized patients with ALRI. ALRI was common in infants (median age = 13.5 months). HRSV was more frequent in cases of bronchiolitis (64%) and during the first year of life (35%). Episodes of HRSV infection occurred between fall and spring, showing higher frequency in 2004 than in 2005. Clinical and radiological criteria were not sufficient to establish the diagnosis of infection with HRSV. Antibiotic therapy was used in 78.8% of episodes of HRSV. CONCLUSIONS: There was a high prevalence of HRSV in children aged 0 to 6 years who were hospitalized for ALRI, predominantly in younger patients or those with bronchiolitis. The circulation of the virus varied in the two years studied. Our results suggest the need for laboratory diagnosis of HRSV in the clinical practice

Research of new refrigerants : prediction of the position of azeotropes for binary mixtures

Paper presented to the 3rd Southern African Solar Energy Conference, South Africa, 11-13 May, 2015.The aim of this paper is to predict the location of azeotropes for binary mixtures using two methods: firstly from the experimental data and secondly with a thermodynamic model. The model is composed of the Peng–Robinson equation of state, the Mathias–Copeman alpha function and the Wong–Sandler mixing rules involving the NRTL model. The binary systems of refrigerants considered in this paper are: Pentafluoroethane (R125) + Propane (R290) [1], 1,1,1-Trifluoroéthane (R143a) + Propane (R290) [2] and Carbon Dioxide (R744) + Propane (R290) [3]. The mixtures mentioned above have been chosen because they are environment friendly with a null ODP and a low GWP. The results proved that there is a good agreement between the predicted values and the experimental data. The presented methods are able of predicting the azeotropic positions.cf201

Production and evaluation of leukocyte- and thrombocyte-rich fibrin membranes in birds

The aim of this study was the preparation and histological evaluation of Leukocyte- and Thrombocyte-Rich Fibrin (L-TRF) membranes obtained from the blood of four bird species. Forty adult healthy birds were divided into four groups of equal size: G1 – macaws, G2 – domestic chickens, G3 – parrots, G4 – toco toucans. A total of 0.5 mL of blood was collected from each bird, put into a glass tube without anticoagulant and centrifuged at 3000 rpm for 10 min. L-TRF membranes produced after compression of the clot were processed for histological analysis. The ratio of thrombocytes/area was not significantly different among Groups G2, G3 and G4, but a significant difference was found between Groups G1 and G2 with the highest thrombocyte concentration/area in G1. The groups did not differ statistically in the number of leukocytes/area. The fibrin-to-cells ratio did not vary statistically among Groups G1, G2 and G3, but this ratio was significantly higher in Group G4 than in the other groups. The thrombocyte-to-leukocyte ratio was the highest in Group G1, but it did not differ among Groups G2, G3 and G4. In conclusion, the centrifugation protocol allowed the production of L-TRF membranes in the four bird species studied. Histologically, cell ratios were analogous in domestic chickens and parrots, and macaws had the highest ratio of thrombocytes

SUSY Higgs at the LHC: Effects of light charginos and neutralinos

In view of the latest LEP data we consider the effects of charginos and neutralinos on the two-photon and bbbar signatures of the Higgs at the LHC. Assuming the usual GUT inspired relation between M_1 and M_2 we show that there are only small regions with moderate tanbeta and large stop mixings that may be dangerous. Pathological models not excluded by LEP which have degeneracy between the sneutrino and the chargino are however a real danger because of large branching fraction of the Higgs into invisibles. We have also studied models where the gaugino masses are not unified at the GUT scale. We take M_1=M_2/10 as an example where large reductions in the signal at the LHC can occur. However we argue that such models with a very light neutralino LSP may give a too large relic density unless the sleptons are light. We then combine this cosmological constraint with neutralino production with light sfermions to further reduce the parameter space that precludes observability of the Higgs at the LHC. We still find regions of parameter space where the drops in the usual Higgs signals at the LHC can be drastic. Nonetheless, in such scenarios where Higgs may escape detection we show that one should be able to produce all charginos and neutralinos. Although the heavier of these could cascade into the Higgs, the rates are not too high and the Higgs may not always be recovered this way.Comment: 37 pages, 17 figures, Latex file, Paper with high resolution figures can be found at http://wwwlapp.in2p3.fr/web/lapp/preplapp/psth/LAPTH774.ps.g

A self-consistent phase-space distribution function for the anisotropic dark matter halo of the Milky Way

Dark Matter (DM) direct detection experiments usually assume the simplest possible ‘Standard Halo Model’ for the Milky Way (MW) halo in which the velocity distribution is Maxwellian. This model assumes that the MW halo is an isotropic, isothermal sphere, hypotheses that are unlikely to be valid in reality. An alternative approach is to derive a self-consistent solution for a particular mass model of the MW (i.e. obtained from its gravitational potential) using the Eddington formalism, which assumes isotropy. In this paper we extend this approach to incorporate an anisotropic phase-space distribution function. We perform Bayesian scans over the parameters defining the mass model of the MW and parameterising the phase-space density, implementing constraints from a wide range of astronomical observations. The scans allow us to estimate the precision reached in the reconstruction of the velocity distribution (for different DM halo profiles). As expected, allowing for an anisotropic velocity tensor increases the uncertainty in the reconstruction of f (v), but the distribution can still be determined with a precision of a factor of 4-5. The mean velocity distribution resembles the isotropic case, however the amplitude of the high-velocity tail is up to a factor of 2 larger. Our results agree with the phenomenological parametrization proposed in Mao et al. (2013) as a good fit to N-body simulations (with or without baryons), since their velocity distribution is contained in our 68% credible interval

Cyclotron effective masses in layered metals

Many layered metals such as quasi-two-dimensional organic molecular crystals show properties consistent with a Fermi liquid description at low temperatures. The effective masses extracted from the temperature dependence of the magnetic oscillations observed in these materials are in the range, m^*_c/m_e \sim 1-7, suggesting that these systems are strongly correlated. However, the ratio m^*_c/m_e contains both the renormalization due to the electron-electron interaction and the periodic potential of the lattice. We show that for any quasi-two-dimensional band structure, the cyclotron mass is proportional to the density of states at the Fermi energy. Due to Luttinger's theorem, this result is also valid in the presence of interactions. We then evaluate m_c for several model band structures for the \beta, \kappa, and \theta families of (BEDT-TTF)_2X, where BEDT-TTF is bis-(ethylenedithia-tetrathiafulvalene) and X is an anion. We find that for \kappa-(BEDT-TTF)_2X, the cyclotron mass of the \beta-orbit, m^{*\beta}_c, is close to 2 m^{*\alpha}_c, where m^{*\alpha}_c is the effective mass of the \alpha- orbit. This result is fairly insensitive to the band structure details. For a wide range of materials we compare values of the cyclotron mass deduced from band structure calculations to values deduced from measurements of magnetic oscillations and the specific heat coefficient.Comment: 12 pages, 3 eps figure

Immunohistochemical subtypes predict the clinical outcome in high-risk node-negative breast cancer patients treated with adjuvant FEC regimen: results of a single-center retrospective study

Prognostic factors for disease-free survival in patients treated before 2005 September: multivariate analysis. (DOCX 15 kb